[1] Initially a physician, Hřib held managerial and consulting positions in state, corporate and non-profit healthcare entities dedicated to digitization, quality control, and consumer protection.

[10] Hřib also subsequently criticized the retaliatory decision by the Chinese government to cancel a planned tour of China by the Prague Philharmonia as a politicization of culture.

[15] In April 2020, Hřib oversaw the removal of a statue dedicated to Soviet marshal Ivan Konev, who is viewed by some in the Czech Republic as a symbol of Soviet-era oppression.

[16] In December 2019, Hřib was among the four mayors of Visegrád Group capitals Prague, Warsaw, Bratislava and Budapest, who signed the Pact of Free Cities, agreeing to protect "common values of freedom, human dignity, democracy, equality, rule of law, social justice, tolerance and cultural diversity".

[17] In April 2020, Hřib was put under police protection after Czech intelligence received evidence of a planned poisoning attack by the Russian secret service.