The Zec de la Grande-Rivière is a zone d'exploitation contrôlée (controlled harvesting zone or ZEC) in the unorganized territory of Mont-Alexandre, in Le Rocher-Percé Regional County Municipality, in administrative region of Gaspésie-Îles-de-la-Madeleine, Quebec, Canada.

The territory of the ZEC extends 23 kilometres (14 mi) along the shore of the river.

Europeans first began settling near the river in the late seventeenth century.

On May 31, 1697, Count Frontenac wrote the deed for the seigneurie of the Grande-Rivière, the first seigneur being Jacques Cochu.

In 1919, it was sold to Americans who established the Grand River Fishing Club, which remained in operation until it was bought out in 1992.