Zeerust is a commercial town situated in the Ngaka Modiri Molema district of North West Province, South Africa.

The original name of the farm on which the town was established was Sefatlhane/Sebatlani (meaning dusty place) belonging to Casper Hendrik Coetzee who bought it in 1858.

On 20 March 1867, the first erven of the newly established Coetzee-Rust were sold per public auction in Potchefstroom, before official recognition of the request to start a town was granted.

That honour belongs to Jacobsdal, a small village about 10 km south of Zeerust situated on the farm Vergenoegd, near the Lucerne station.

A mall exists named Autumn Leaf, and a few complexes are in the towns CBD The Zeerust Chromium Mine was first developed in 1942.