Zeil am Main is a town in the Haßberge district in Lower Franconia, an area in the federal state of Bavaria, Germany.

The earliest evidence of Zeil am Main as a city is in a 1018 AD deed of donation signed by Henry II, King of the Romans.

Bishop Lamprecht of Prun granted municipal law to the city in 1379 and allowed citizens of Zeil to build protective fortifications.

King Wenceslaus of Bohemia entitled the community with special laws to use the river Main commercially in 1397.

In the early 19th century, church lands were secularized, and Zeil am Main became a municipality within Bavaria by edict in 1818.