As the westernmost district of Frankfurt, Zeilsheim is somewhat rural in character and the surrounding fields can give a clear view of the Taunus mountains.

Zeilsheim borders Kriftel in the west, Liederbach am Taunus in the north, the district of Unterliederbach in the northeast, Höchst in the east, and Sindlingen in the southeast.

The main street of the district is the Landesstraße 3018 that lead through the L 3016 from Kelkheim through Unterliederbach, through Zeilsheim until Hofheim am Taunus.

A settlement in Zeilsheim was initiated by Hoechst AG to provide worker housing located near its factories.

Zeilsheim became famous for its camp created by the Allies to hold Displaced Persons and exiles after World War II, and in 1946 it was visited by Zionist leader (later Israeli prime minister) David Ben-Gurion and former American First Lady Eleanor Roosevelt.