As of 2022, the Zeitz MOCAA Global Council includes Acha Leke, Bame Pule, Julie Mehretu, Michèle Sandoz, and Wangechi Mutu.

[10] According to CEO David Green, the decision to transform and renovate the building for the new museum would "breathe life into the Silo district and act as a draw card to a venture that is non-commercial in nature ... specifically for the enjoyment of all the continent’s citizens".

The architects, Heatherwick Studio, aimed to conserve and celebrate the original structure's industrial heritage, while simultaneously excavating large open spaces from the 42 densely-packed concrete cylinders from which it was comprised.

Her work in photography, photomontage, prints, textiles, embroidery, installation, and performance deals with history, memory, and personal narrative, and emphasises historical gaps and overlooked female figures.

[15] Curated by Koyo Kouoh, Storm Janse Van Rensburg, and Tammy Langtry, the exhibition centres around Theodorah Mthetyane, Marasela’s fictional alter ego who was inspired by, and is a dedication to her mother and works as an avatar for the artist to live and explore the experiences of Black women in Africa.

[22] November 7, 2019 - March 26, 2023 Inaugurating a dedicated space for the permanent collection of Zeitz MOCAA on the fourth floor, this exhibition is organised around thought-provoking pairings.

[25] Using interactive and multi-sensory experiences with art in the underground tunnels of the museum, the exhibition was based around African storytelling, taking its title from an Ekoi legend of a mouse who visits houses, gathering stories and weaving them together into new life forms.

[26] September 12, 2018 - May 31, 2019 On the third level of the museum, this exhibition of works by 29 Zimbabwean artists defined "painting" in a broad sense, provided a synopsis of the medium's applications and histories within Zimbabwe.

In the wake of Robert Mugabe's resignation from the office of the presidency after 37 years in power, the exhibition addressed the "End of an Era" through seven thematic sections, each offering perspectives on the state of painting and political subjectivity in Zimbabwe.

Placing first in Hyperallergic's "Our Top 15 Exhibitions Around the World," for 2019, Five Bhobh "was able to capture not only the individual brilliance of each of the 29 artists, but it offered us insight into how their work clustered into relevant topics without feeling forced.

Accompanying the exhibition was Zeitz MOCAA's first comprehensive catalogue, also titled Five Bhobh: Painting at the End of an Era, and featuring written contributions by Azu Nwagbogu, Tandazani Dhlakama, Raphael Chikukwa, Doreen Sibanda, Helen Lieros, Derek Huggins, George Shire, heeten bhagat, and Hayden Proud.

Taking its title from a text work by African-American artist Hank Willis Thomas the exhibition offered answers to the question “How will I be represented in the museum?” by presenting a wide range of painting, sculpture, photography, installation, video, and drawing meant to speak to a plurality of African and Diasporic identities.

Works by 41 artists were exhibited, including El Anatsui, Njideka Akunyili Crosby, Nicholas Hlobo, Rashid Johnson, Isaac Julien, William Kentridge, Glenn Ligon, Misheck Masamvu, Zanele Muholi, Wangechi Mutu, Chris Ofili, Athi-Patra Ruga, Mary Sibande, and Kehinde Wiley.

The Mobile Museum will be designed by Kenya-born South African architect and social activist Kevin Kimwelle highlighted by Metropolis Magazine in 2020 as a Gamer Changer.

Classes are held on a weekly basis within the museum's classrooms to provide a safe space for workshops for students as young as six years old through to high school graduation.