Zena Virginia Keefe (June 26, 1896 – November 16, 1977) was an American actress in silent film, active in the 1910s and 1920s.

[2] For three seasons, Keefe portrayed Little Mother in a touring production of The Fatal Wedding.

She left the theater to appear in films with Vitagraph, but after less than a year with that company she began performing as a featured attraction in Keith Vaudeville.

Keefe's work in films included the serial The Perils of Girl Reporters.

[citation needed] Keefe died on November 16, 1977, in Danvers, Massachusetts.