[1][2] In the late 19th century the first bishops of the Turkistan eparchy discussed the need for a Russian Orthodox Church in Almaty.

The cathedral survived the 1911 earthquake with minimal damage, even though it was built without any nails, which some bishops attributed to divine intervention.

After the Russian Revolution the cathedral was used to house the Central State Museum of the Kazakh Soviet Socialist Republic.

[5] On June 2, 2007, the National Bank of Kazakhstan put into circulation the coin "Cathedral Cathedral" (proof quality) of 500 tenge in 925 sterling silver with the mintage of 4000 pieces with the aim to promote the understanding of the culture of Kazakhstan, and to favor the idea of religion as a peaceful teaching about spiritual and moral self-improvement of person.

The coin bears the coat of arms of Kazakhstan as well as inscriptions divided by dots on its circumference saying "500 ТЕҢГЕ", "ҚАЗАҚСТАН РЕСПУБЛИКАСЫ" in Kazakh and "РЕСПУБЛИКА КАЗАХСТАН" in Russian are depicted on the obverse.