Also known as "Zenon the Destroyer", Konopka played for the Mighty Ducks of Anaheim, Columbus Blue Jackets, Tampa Bay Lightning, New York Islanders, Ottawa Senators, Minnesota Wild, and Buffalo Sabres during his National Hockey League (NHL) career.

[citation needed] After three minor league seasons with various teams in the ECHL and AHL, Konopka made his NHL debut in 2005–2006, playing 23 games for the Mighty Ducks of Anaheim.

[citation needed] After the Ducks were eliminated, he returned to Portland in the AHL, where he led all playoff scorers in power play goals and assists.

[citation needed] On July 10, 2008, Konopka signed a two-year contract with the Tampa Bay Lightning as a free agent.

During the 2012 Stanley Cup playoffs, Konopka directed verbal abuse towards a New York Rangers player during a live television interview.

[5] On May 15, 2014, Konopka was suspended for 20 games following violation of the NHL/NHLPA Performance Enhancing Substances Program after taking dehydroepiandrosterone on a doctor's suggestion.

[7] On April 1, 2017, Konopka officially retired from hockey when he signed a one-day contract with the Syracuse Crunch to close out his career.

Konopka is also an entrepreneur and owner of Prime Wine Products,[9] and partners with local charities to help children's programs.