Jetisu Region (Kazakh: Жетісу облысы, romanized: Jetısu oblysy, IPA: [ʒʲetɘˈsu wobɫɤˈsɤ]; Russian: Жетысуская область, IPA: [ʐɨtɨˈsuskəjə ˈobləsʲtʲ]), formerly spelled Zhetysu Region, is one of the Regions of Kazakhstan.

Kazakh President Kassym-Jomart Tokayev announced on March 16, 2022, that the region would be created.

The area split off from Almaty Region when Tokayev's decree came into force on June 8, 2022.

[4] On June 11, 2022, Beibit Isabayev was appointed as akim of the region.

It is named after the historical Zhetysu region of Central Asia, which is primarily situated within the modern-day region.