After stage roles in Long Day's Journey into Night[2] and Julius Caesar,[6] he made his West End debut as Dr. Aziz in A Passage to India[7] on 20 April 1960 at the Comedy Theatre.
He made his film debut in Lawrence of Arabia (1962), playing the role of Tafas (the Arab guide who is shot by Omar Sharif for drinking water from the wrong well).
[9] Following differences with the military regime of General Zia-ul-Haq, Mohyeddin returned to the United Kingdom in the late 1970s.
During the 1980s Mohyeddin worked in Birmingham, UK, where he produced Central Television's flagship multicultural programme Here and Now (1986–1989), a weekly magazine program.
[3] Mohyeddin then travelled the world giving Urdu poetry and prose recitations,[7] as well as readings of English letters and literature.
He commented unfavourably on reciters who would habitually pause after every rhyming couplet, or "hammer" out the verses without regard for rhythm.