The electoral district of Zierikzee was created in 1848 for the first direct election of the House of Representatives.
It comprised the islands of Schouwen-Duiveland, Tholen and Sint Philipsland, all part of the province of Zeeland.
Zierikzee was retained as a single member district in 1850, although much of Tholen was transferred to the district of Goes, while the island of Goeree-Overflakkee, part of the province of South Holland, was transferred from Brielle to Zierikzee.
[4] The district of Zierikzee was abolished upon the introduction of party-list proportional representation in 1918.
The subsequent by-election was won by the Anti-Revolutionary candidate Jozef Jan Pompe van Meerdervoort, but in 1905 the district was won back by the Liberal Rudolf Patijn, who continued to represent the district until its abolition in 1918.