[2][4] Zinnia grandiflora is used by many Native American tribes for its medicinal properties as well as for its vibrant yellow color for paint and dyes.

This plant is used by several Native American groups, including the Zuni and Navajo, for medicinal and ceremonial purposes.

[6] The Acoma and Laguna Indians used Zinnia grandiflora to heal kidney illnesses by drinking an infusion of it.

The wildflowers were Salvia farinacea (mealy cup sage), Berlandiera lyrata (chocolate daisy), Ratibida columnaris (Mexican hat), Oenothera elata (Hooker’s evening primrose), Zinnia grandiflora (plains zinnia), and Monarda citriodora (lemon horsemint).

Zinagrandinolide E was taken from Zinnia grandiflora plants and given to mice with either carrageenan-induced inflammation and tactile allodynia hyperglycemia.

Zinnia grandiflora is a small flat-topped or rounded subshrub growing up to 22 cm (8+1⁄2 in) tall with many slender, branching stems.

[10] Rhizomes are stems that grow horizontally to the ground making them very sturdy which helps stop erosion.