Sali made her debut in 2000 with her first studio album released by Dost Music, Ba-Ba, that contains only Turkish songs.

[2][3] After completing her primary and secondary education in Cyprus following their return to the country,[3] she graduated from the Polatpaşa High School in Lysi.

[8][9] In September 2004, her second studio album that contains Turkish and Greek pop songs Amman Kuzum, was released by Zorba Müzik.

[12] Her third studio album that was released by Ozan Video in September 2006 contained Greek and Turkish language songs.

[14] "Zordur Oğlum" won the online voting for Eurodance 2007 which was made before the actual event, but couldn't get a place in the competition.

[18] She was a Greek singer in Son Osmanlı Yandım Ali which was released in January 2007 making her first film appearance.

[19] At the same month Kalan Müzik released the songs "Alim" and "Kanaryam" by Sali which were produced for the film's soundtrack.

[33] She appeared as herself in the New Year's Eve special episode of the Kanal D series Geniş Aile, broadcast on 31 December 2009.

[35] According to the Nielsen Media Research data, the single reached to the number one place in the chart of the most played songs on Turkish radio stations.

[43] In February 2011, her first compilation album Collection which contains the songs from Mor Yılar and Herkes Evine, among with "Bizde Böyle", "Rüya" and "Bize Yeter" was released by DMC.

[48] In February 2012, she released "Alışkın Değiliz", a promotion single for her upcoming fifth studio album Sonsuz Ol, that was accompanied with a music video.

[50][51] Accompanying music videos were released for "Favori Aşkım",[52] "Yanabiliriz",[53] "Her Şey Çok Güzel Olacak",[54] "Yine Geceler", "Deli" and "Senin Olsun".

[61] In November 2013, a non-album single which was written and composed by Sinan Akçıl "Gelemiyorum Yanına" was released by GNL Entertainment.

[66] She, Volkan Konak and Fettah Can voiced "Arzuhalcinin Yazamadıkları" in Büyük Resim, an album released in April 2014 for the 15th anniversary of the establishing of the Turkey Handicapped Sports, Education and Assistance Foundation.

[68] She performed "Naparsan Yap" in the Ozan Doğulu album 130 Bpm Moderato (July 2014) and appeared in the music video of the song.

[69][70] Her non-album singe "Benim Adım Leyla" was released by DMC along with an accompanying music video in September 2014.

[81] She made a guest appearance in the 11th episode of Buyur Burdan Yak, a stage show that was played at the Beşiktaş Cultural Center and broadcast on Kanal D on 11 October 2015.

[86] In January 2017, she collaborated with Enbe Orkestrası on the band's single "Bir Melekten Hediye", and she appeared on its music video which was released by DMC.

[89] In November, her first English language single "Magic" that features Anthony Johnson and its music video were released by DMC.

[90] In December 2017, she received nominations for the Pop Singer of the Year-Female, and the Song of the Year by "Bir Melekten Hediye" (with Enbe Orkestrası) and "Yağmur" (with Ozan Doğulu) at the 44th Golden Butterfly Awards.

[96] On 6 February 2019 she released a cover version and an accompanying music video of Bob Marley's "No Woman, No Cry" (1974) on YouTube, as a tribute to mark his 74th birthday.

[97] On 14 March a cover version of Ferdi Tayfur's song "Bana da Söyle" (1991) was released by DMC, with an accompanying music video.

The song was written by Tuğçe Ören Nihat Odabaşı directed its music video, in which Sali's husband also appeared.