She left after two members of her Ular tribe alliance (Richard and Jackie) aligned with the eventual winner, Charlotte, to vote against her.

[14] Lyons featured in The Independent's tenth annual Pink List for 2009, detailing the 101 most influential lesbian and gay people in Britain.

Reviews were favourable, with a critic from Australian Stage reporting: "I have renewed faith in stand-up comedy after seeing UK comedian Zoe Lyons.

[16] Lyons' television credits include appearances on Mock the Week,[17] Michael McIntyre's Comedy Roadshow, The Paul O'Grady Show, The Wright Stuff (as a regular guest panellist), Room 101, Dave's One Night Stand and QI.

[18] In 2021, Lyons hosted her own teatime TV quiz show, Lightning, on BBC Two,[19] as well as Stand Up and Deliver on Channel 4, where she mentored Katie McGlynn.