She was a regular on the CBS sitcom Young Sheldon as Mary Cooper, a character earlier portrayed by her mother Laurie Metcalf on The Big Bang Theory.
Perry's performance as Mary Cooper earned a Critics' Choice Television Award nomination.
[2][3] Her first television roles were two appearances as Jackie Harris (as seen in flashback) on the ABC sitcom Roseanne, the character portrayed by her mother.
[6] In 2015, she performed alongside her father and Kevin McKidd in Eugene O'Neill's Pulitzer Prize-winning drama Anna Christie at the Odyssey Theatre Ensemble in West Los Angeles.
[4][9] She reprised the role of Mary Cooper on Georgie & Mandy's First Marriage, which premiered on CBS on October 17, 2024.