The TV movie was broadcast in the US on CBS with some controversy as it reportedly "likened the nation's acceptance of the Bush administration's pre-emptive strike on Iraq to the climate of fear that allowed Hitler to prosper".
[9] In Agatha Christie's Poirot's Death on the Nile (2004), Telford played Rosalie Otterbourne, one of the cruise passengers alongside Emily Blunt, James Fox, and David Suchet.
She played Alison Jackman, a young trainee at the fictional PR firm of Prentiss McCabe headed by Stephen Fry in the BBC's Absolute Power (2003–2005), and trauma doctor Jane Cameron in The Golden Hour (2005), a four part ITV miniseries.
In 2006 Telford played Emily Trefusis in Agatha Christie's Marple's The Sittaford Mystery, produced jointly by Granada and WGBH-Boston.
In 2009 Telford appeared in several other procedural dramas including Law & Order: UK (2009), the second season of Criminal Justice (2009) where she played the defence barrister for Maxine Peake’s character Julie, and Collision (2009) which was broadcast in the US under the PBS Masterpiece Contemporary.
She also appeared in Episodes 2 and 3 of the first season of the BBC's Sherlock (2010) as Sarah, a physician colleague and love interest of Dr. John Watson, played by her Men Only co-star Martin Freeman.
Her role as Bella Cross, the daughter of one of the main suspects in the first season of Unforgotten (2015), reunited her with Nicola Walker, her former co-star in The Last Train.
She appeared in other British TV series including Death in Paradise (2018) as Michelle Devaux, a professional poker player, and Grantchester (2019) as Professor Jean Simms, Head of the Computing Department at the University of Cambridge, set in the 1950s.