An official of Poland's Ministry of the Interior in the Second Polish Republic (1921–1939), she was interned in Romania after the outbreak of World War II (1939–1945).

[2] On 1 January 1921, she was employed at the budget department of the Ministry of the Interior in Warsaw, where she worked successively as an intern, controller and treasurer in the rank of referendary, until the outbreak of World War II.

[2] On September 7, 1939, after the German invasion of Poland, Zofia Vetulani was evacuated from Warsaw at the request of the interior minister, with the order to export money, seals and ministerial documents from the country.

[2] From December 1939 to February 1940, she served as the social secretary of the women's circle board at the American Commission for Aid to Poles – YMCA in the Brăila refugee camp.

[2] From February to August 1940, she was the secretary of Jerzy Lechowski, the Consul General of the Republic of Poland for the districts of Brăila, Galați and Tulcea.

[2] In July 1945, upon returning to Poland, Zofia Vetulani volunteered to work at the Ministry of Public Administration with a request for a delegation to Olsztyn.