She has appeared in films such as Warsaw 44 and Afterimage, and television programmes such as Medics, The Romanoffs and World on Fire.

She appeared in the made-for-television film The Morality of Mrs. Dulska in 2013, in one episode of Głęboka woda the same year and in Medics in 2014.

Andrzej Wajda had seen Zofia in a play and had decided to cast her in Afterimage, which later turned out to be the director's last production.

In 2019 Wichłacz starred in the drama series DNA, a multi-company production about illegal adoptions, directed by Henrik Ruben Genz and Kasper Gaardsøe.

[2] That same year, she portrayed Kasia, a Polish waitress, in the British drama series World on Fire.