The game revolves around the floating samurai head Namakubi goes to the United States to destroy Darc Seed—an alien who crashed to Earth via a meteorite in 1999, turned all the American people into zombies, and took control of various deadly weapons.

Takane Ōkubo, its designer, had previously worked on Bōken Danshaku Don: The Lost Sunheart,[2] a similar title for the NEC PC Engine.

[7] The plot of Zombie Nation takes place in 1999, when a meteor known as "Darc Seed" (Eva in the Japanese version) crashes in the Nevada desert.

He then heads to the United States to destroy Darc Seed, free the American people from the looming zombification and reclaim the samurai sword Shura.

[15] Mashable, in ranking Zombie Nation the second-weirdest video game of all time, claimed it "brings the side-scrolling shooter genre to a weird and gross new height.

As challenging as it is confusing, the high point of this game is the chance to take down an animated, evil Statue of Liberty.

"[16] On the other hand, the Japanese version is criticized due to its difficulty and gameplay, and considered a kuso-gē (クソゲー, lit.

Seigaku Dennou Kenkyuubu (進め！！静学電脳研究部, Shiawase no katachi), published in the Gamest Comics collection from April 1999, drawn by Kouta Hirano.