[4] Damania was a practicing hospitalist (physician specializing in acutely ill patients admitted to the hospital) at Stanford University School of Medicine for 10 years.

He was then the founder of Turntable Health, a direct primary care clinic in Downtown Las Vegas that was funded by Zappos CEO Tony Hsieh.

[6] While there he completed a research thesis in a genetics lab on integrin-mediated cell-cell adhesion pathways in the Drosophila melanogaster model with James Fristrom.

With the encouragement of Tony Hsieh, the CEO of Zappos.com, Damania began writing, performing, and filming musical parodies about the frustrations of work as a doctor, posting them on YouTube to immediate success.

[14] Since beginning work on the clinic, Damania has been named one of the "top 14 people to watch in 2014"[15] by Las Vegas Weekly, and has been profiled in The Atlantic Monthly,[16] Xconomy,[17] Wired, Venture Beat, Gizmodo, MSNBC, and USA Today.

[4] When his first music video (Immunize, based on Billionaire by Travie McCoy and Bruno Mars) was viewed 200,000 times, it got Damania death threats from anti-vaccination activists, who also mounted an unsuccessful campaign to get him fired.

Damania spent time reading anti-vaccination groups online and the few medical experts who were attempting to push against the tide of disinformation, such as David Gorski.

[26] His videos feature a rotating cast of several characters, also practicing doctors, including, most often, Dr. Harry, a pediatrician, and Doc Quixote, Dr. Diego, and others.

[4] He is also currently collaborating with Devin Moore, a composer, bassist in the band “Rabbit!,” and member of Downtown Project's music development team in Las Vegas.

[29] The clinic opened in December 2013 and was an integral part of Hsieh's Downtown Project of revitalizing Las Vegas and re-visualizing urban spaces.