[1][2] He quickly made an impact at Dens Park, alerting fellow Scottish Premier League team Rangers, whom Khizanishvili joined on a Bosman transfer in July 2003 as a replacement for Blackburn Rovers-bound defender Lorenzo Amoruso.

[3] Despite making 35 appearances in his first campaign at Ibrox, Khizanishvili gradually fell out of favour and, on 31 August 2005, he was allowed to move on loan for the rest of the season to Blackburn in the English FA Premier League.

He was a key part of Blackburn's team in the 2006-07 season, starting more than half the matches as the club competed domestically and in the UEFA Cup.

His first appearance of the 2009–10 campaign came on 25 August, when he started the League Cup 2nd Round tie against Gillingham at Priestfield Stadium, playing the full 90 minutes alongside Gael Givet in a 3–1 win.

On 13 March 2011, Khizanishvili completed the full 90 minutes against Manchester City at Eastlands in a 1–0 FA Cup quarter-final loss.

[10] After he retired from football in the summer 2017, Khizanishvili was appointed as the assistant manager of Gia Geguchadze at the Georgian U-21 national team.