Zygote is the debut studio album by American singer-songwriter John Popper.

[3] Produced by Terry Manning, it was released on September 7, 1999, less than a month after the death of bassist Bobby Sheehan (Popper's friend and fellow member of the band Blues Traveler).

Accompanying Popper on the album were Carter Beauford (of the Dave Matthews Band) on drums, and Crugie Riccio on guitar, Rob Clores, and Dave Ares (all of Cycomotogoat).

It peaked at No.

185 on the Billboard 200.