The site is also the location of Lake Tuendae, originally part of the spa, and now a refuge habitat of the endangered Mohave tui chub.

Curtis Howe Springer made up the name Zzyzx and gave it to the area in 1944, claiming it to be the last word in the English language.

In 1977, Borgman noted his source as being "an old, undated map of San Bernardino County published by the Automobile Club of Southern California" and repeated his description of the settlement as being "a hydrologic feature and privately owned spa in San Bernardino County, California, about 8.5 miles south of Baker, on the western edge of Soda Dry Lake, off the abandoned right-of-way of the old Tonopah and Tidewater Railroad.

[12] The 2006 films Zzyzx and Zyzzyx Road both involve characters taking advantage of the unpopulated desert area.

The Internet TV show Smartypants S1 E7 (2024) produced by Dropout (formerly CollegeHumor) has a presentation by Carolyn Page about the history of the town.