[1] Her father was a novelist, journalist, politician and former minister, as well as the major shareholder of Mohlabani Property Company, and left her a sizeable estate.
[4][5] Khaketla did her primary and secondary schooling Maseru, before receiving a Bachelor of Education from the National University of Lesotho in 1980.
[4] Her thesis was titled "An analysis of the Lesotho Junior Certificate Mathematics Examination and its impact on instructions".
[4] She worked at the Institute of Development Management in Lesotho and Botswana from 1996 until 2001 before becoming the director of the Centre for Accounting Studies.
In 2011, Khaketla was one of seven women ministers in the Cabinet, alongside: Mannete Ramali, Maphoka Motoboli, Mathabiso Lepono, Mphu Keneileo Ramatlapeng, Mpeo Mahase-Moiloa and Pontso Suzan Matumelo Sekatle.