With the support of allies, they promoted an uprising in Plasencia in mid-1488, claiming the liberation of the municipality, setting up a siege of the castle and calling on King Ferdinand II to hand it over to Zuñiga.

Zúñiga tried unsuccessfully to enlist the help of Queen Isabella and King Ferdinand encouraged the rebels in their fight against the duke and, aided by his army, had Plasencia handed over to the Catholic Monarchs.

As present in Ferdinand II's oath upon taking the city, he promises to defend the municipality and residents of Plasencia in their forals, privileges, mercies, liberties, franchises, ordinances, uses, and customs, as Count Pedro de Zúñiga and his son Álvaro had done.

Years later, on February 23, 1495, the city of Plasencia petitioned the Catholic Monarchs to confirm the franchises, liberties, and exemptions that the townspeople had when they had the dukes of Álvaro and his grandson as their lord.

In June 1482, King Ferdinand II began the conquest of Granada by focusing on the united armies of the great ones of Castile in Córdoba and marching towards Loja.

The 2nd Count of Tendilla, Íñigo López de Mendoza, received violent blows of club and almost fell into enemy hands, being saved from such fate by the young Zúñiga.

King Ferdinand II, the dukes of Nájera, Medinaceli, and of Plasencia (the latter represented by his grandson Álvaro), and other nobles concentrated their forces in Córdoba in April 1485 to wage war on the Moors.

[13] Zúñiga also participated in the conquest of Baza, Guadix, and Almeria, and in the final victory of the War of Granada, which ended with the surrender of the Moorish king Boabdil.

83 laws are agreed upon on March 7, 1505, regulating the succession and recognizing the King of Aragon Ferdinand II as governor of the Kingdom of Castile following the will of Queen Isabella.

[17] The Conjuring was initiated in 1505 by Juan Manuel, Lord of Belmonte, and was joined by the dukes of Nájera, Béjar, Medina-Sidonia, the count of Benavente, and the marquis of Villena, who did not recognize the agreement of the Cortes de Toro nor Fernando II's rule of the kingdom.

Philip develops intense diplomatic activity in Castile, addressing letters to the grandees (most powerful nobles), to high ecclesiastical dignitaries, and to main cities and towns with votes in the courts.

[19] Zúñiga presided over the entourage that in January 1524 took the Infanta Catharine of Austria, younger sister of Emperor Charles V and future wife of King John III of Portugal, to the Portuguese border in Badajoz.