In the International Phonetic Alphabet, /ẽ/ represents a nasalized [e] sound.
It is the 5th letter in the Guaraní alphabet and widely used in other Amerindian languages in Brazil, such as Kaingang, representing this nasalized [ẽ] sound.
In Romagnol, ẽ has been proposed to represent [ẽː], e.g. galẽna [gaˈlẽːna] ("hen").
Commonly found in medieval and Renaissance-era texts, both in Latin and vernacular languages such as Old Spanish and Middle French, standing for en and em before a consonant or at the end of a word.
For example, Old Spanish tiẽpo for tiempo, riẽdas for riendas, fazẽ for fazen.