[1] Patients with acute GPP experience the eruption of multiple isolated sterile pustules generalized over the body, recurrent fevers, fatigue, and laboratory abnormalities (elevated ESR, elevated CRP, combined with leukocytosis).
[2] Kogoj's spongiform pustules can be observed via histopathology to confirm acute GPP.
[2] Acute GPP typically requires inpatient management including both topical and systemic therapy, and supportive measures.
[5][6] The disorder has been named after Leo Ritter von Zombusch, who first described two cases of a brother and a sister in 1910.
[7] The patients experienced patterns of redness and pustule formation over several years, often associated with use of topical medications.