The cartridge uses a slightly shorter, semi-rimmed case similar to that of the .220 Swift to function in lever-action rifles.

As introduced in Hornady's LEVERevolution line of cartridges, it is the highest velocity production cartridge designed for lever action rifles with tubular magazines.

[2][3] The .308 Marlin Express was designed to produce performance similar to the .308 Winchester.

This would give lever-action hunters improved performance over their .30-30 Winchester rounds.

As of 2010, Hornady and Remington remain the only two manufacturers of loaded ammunition in .308 Marlin Express.