It is currently the most powerful revolver cartridge in the world, offering a similar level of ballistic performance to African stopping rifles, such as the .416 Rigby and .470 Nitro Express.

[6] A 10-inch barrel revolver chambered for the cartridge is capable of penetrating 103 inches of 10% Clear Ballistics gel.

They initially used the .375 Ruger for a parent case, fireforming the brass cylindrical and threading the bases for rims.

Since the case is simply a lengthened version of the .500 S&W Magnum, the cylinder wall thickness remains the same on a firearm converted to the larger cartridge.

[9] To ensure manageable recoil in converted revolvers, all .500 Bushwhacker conversions produced by TII Armory include the installation of a rifle-style muzzle brake.