The series is centred on Jess Mastriani, played by Caterina Scorsone, a woman in her twenties[1] who receives psychic abilities after being hit by lightning.
She is employed by a special FBI Task Force because she has visions which, once interpreted, contain clues that will help her find missing people.
Other stars of the series during its first season included Justina Machado as Sunny Estrada, and Dean McDermott as Alan Coyle.
Taking Sunny's place was Mark Consuelos, and Justin Louis assumed the role of the Assistant Director John Pollock.
The series finale aired on February 5, 2006 alongside the show's partner Strong Medicine and, in April 2006, it was revealed that Missing had been cancelled after a successful three-year, fifty-six-episode run.