[7] In the winter of 2015, Les and Brady first produced music together, recording in Laura's Chicago apartment[8][6] and eventually self-releasing their first EP, 100 gecs, on July 12, 2016.

[14] In November 2019, the duo appeared on the Adult Swim web series FishCenter Live and performed the songs "800db Cloud" and "Stupid Horse" in front of a green screen backdrop of an aquarium.

[24] Towards the end of 2019, Brady announced a remix album[25] by the duo tentatively titled 1000 gecs & th3 phant0m m3nac3 and set to feature artists including A. G. Cook.

[45] Several 2022 music festival lineups with 100 gecs were announced in late 2021 and 2022, such as BUKU, set to take place in New Orleans in March;[46] Ceremonia in Mexico City in April;[47] Coachella in Indio, California in April;[48] Forecastle in Louisville in May;[49] Governors Ball in Queens, New York in June (after pulling out of the festival the previous year);[50] Bonnaroo in Manchester, Tennessee in June,[51] and Lollapalooza, Chicago in August.

[55] According to Pitchfork's Steven Horowitz, the album is more mainstream and "mature" in its sound than their previous works, and would feature songs where Les is heard without the duo's trademark autotune.

[56] The North American leg of the 10000 gecs Tour started on October 8 at the Fox Theater in Oakland, California,[57][40] and ended on December 9, at the Terminal 5 music venue in New York City,[40] which was also broadcast on the live streaming service Twitch.

[58] On November 19, 100 gecs released the first single off the album, "MeMeMe", during their tour, with an accompanying kaleidoscopic music video featuring the pair dancing in wizard robes.

[62] A music video for the track was released on May 16, 2022, featuring the duo flying around a desert while the news reports on their actions, as well as a cameo from a Danny Devito impersonator.

[67] After numerous delays, 10,000 gecs was released on March 17, 2023, alongside the music video for the album's final single "Dumbest Girl Alive", to positive reviews.

Julianne Escobedo Shepherd of Pitchfork describes the project as "a reevaluation of the most declassé and dunderheaded rock genres that roiled the 2000s",[68] most notably with singles like "Doritos & Fritos" and "Hollywood Baby".

Mosi Reeves of Rolling Stone comments that the project shows that "100 gecs haven't lost their sense of joy, even as they codify their innovations into something resembling normality.

[72][6] Soon, the 100 gecs tree was found, revealed to be located in an Acuity Brands-owned office park in Des Plaines, Illinois, near O'Hare International Airport.

[84] The duo works on tracks by sending Logic Pro project files between the two,[16][5] iterating songs each time[85][86]—Les called the process "sort of an exquisite corpse type thing".

[5] Les calls their musical process "[v]ery much almost an improv mentality"[5] and has said that they "try to have fun and write songs that we would want to listen to",[89] adding that "the whole idea of labeling genres is not super important to us".