The 100th Kazakh Rifle Brigade was a military unit in the Red Army of the Soviet Union during World War II.

The 100th Rifle Brigade was formed based on an order by the People's Commissariat of Defense and passed down by the Central Asian Military District on 26 November 1941.

This breach in the German line would be where the brigade would operate until 7 December, occupying a number of settlements in the area.

During the Battle of Velikiye Luki, the brigade suffered heavy losses and Lieutenant Colonel Voronkov was killed.

However, on 15 October the brigade conducted an operation to capture the village of Bolshoi Ivan and the area of the Izocha rail station.