It is known for its glass-clad, four-story atrium which functions as public space.

Its art pavilion has included commissions by painter Charles Arnoldi and sculptor Larry Bell.

On warm days, the building at street level is opened.

Hines sold 101 Second Street to Invesco Real Estate for about $297 million in January 2014.

[5] As of May 2023, during what the San Francisco Chronicle described as "Downtown San Francisco['s] worst office vacancy crisis on record," 101 Second Street had a vacancy rate of 21.1%.