[citation needed] The building served as the West Coast headquarters for the National Broadcasting Company from 1927 to 1942;[8] the executive offices were located on the 21st floor and the studio offices were located on the 22nd.

The 22nd floor was later occupied by peer-to-peer lending firm Prosper Marketplace.

[citation needed] 111 Sutter Street was the fictional location of the "Spade & Archer" detective agency in Dashiell Hammett's 1930 book, "The Maltese Falcon".

According to Hammett, Sam Spade's office was located on the 5th floor.

[citation needed] As of May 2023, during what the San Francisco Chronicle described as "Downtown San Francisco['s] worst office vacancy crisis on record," 111 Sutter Street had a vacancy rate of 43.9%.