According to USA Today and other outlets ahead of it 25th anniversary BET CEO announce that a reboot is in the works with a 2025 release [1] The show was originally produced in East Harlem, New York City, and the title of the show is derived from the original studio location, NEP's Metropolis Studios, at East 106th Street and Park Avenue.

In 2001, Viacom's acquisition of BET prompted a change to the CBS Broadcast Center at 524 West 57th Street between 10th & 11th Avenues, in the Hell's Kitchen section of Midtown Manhattan, turning its title into a misnomer for the rest of its history.

On August 1, 2005, 106 & Park had been presented by television personality and model Julissa Bermudez and Rap City: Tha Basement's Big Tigger until July 3, 2006 as temporary replacements for the show before they could find another female co-host for Terrence J.

Thus beginning a nationwide search for the next hosts of 106 & Park, which started on June 1, 2012 and ended on October 1, 2012.

They included Jim Jones, French Montana, Julissa and Big Tigger (former hosts of the show), 2 Chainz, Ace Hood, Alicia Keys, Amar'e Stoudemire, Big Sean, B.o.B, Bobby V., Brandy Norwood, Busta Rhymes, Cassidy, Ciara, Common, Doug E. Fresh, DMX, Dwyane Wade, Elle Varner, E-40, Future, Jacob Latimore, Keke Palmer, Mary J. Blige, MGK, Mike Epps, Ne-Yo, Shannon Brown and Monica, Stalley, Rick Ross, Robin Thicke, T.I., Wyclef Jean and Bow Wow (who later hosted with Miss Mykie for next month).

[3] On October 1, 2012, the new hosts for 106 & Park were announced, including Shad "Bow Wow" Moss,[4] Jordan "Shorty da Prince" Johnson,[4] Kimberly "Paigion" Walker[4] and Mykel "Miss Mykie" Gray.

New segments included "The Mykie Report", "The Battle of the Sexes", "Girl Chat", "Inside the Rapper's Studio", "Virtually Famous" and other programs with 106 & Park guest correspondent "Franky J" in future works.

The past hosts, A. J. Calloway & Free (original; 2000–2005), Julissa & Big Tigger (2005–2006), Terrence J & Rocsi (2006–2012) and Shorty da Prince, Paigion and Miss Mykie of "The Search" (2012–2013) also returned to the show to honor with current hosts Bow Wow and Keshia Chanté with a special guest appearances by Wale and Keyshia Cole.

The final video to be retired was "Ridin'" by Chamillionaire featuring Krayzie Bone on December 19, 2014.