The 10th Iowa Infantry Regiment was an infantry regiment that served in the Union Army during the American Civil War.

[1] The 10th Iowa Infantry was organized at Iowa City, Iowa, and Montezuma, Iowa, and mustered into Federal service on September 6 (9 companies)[1] and September 28, 1861 (remaining company).

[1] The regiment was mustered out on August 15, 1865, in Little Rock, Arkansas.

Total enrollment was 1319.

The regiment lost 6 officers and 95 enlisted men who were killed in action or who died of their wounds and 134 enlisted men who died of disease, for a total of 235 fatalities.