[1] The 110th New York Infantry was organized at Oswego, New York beginning May 23, 1862 and mustered in for three-years service on August 27, 1862[2] under the command of Colonel DeWitt Clinton Littlejohn.

The regiment was attached to the defenses of Baltimore, Maryland, VIII Corps, Middle Department, to October 1862.

3rd Brigade, 3rd Division, XIX Corps, Department of the Gulf, to February 1863.

[2] The 110th New York Infantry mustered out of service on August 28, 1865.

Moved to Fort Monroe, Virginia, November 6, then sailed for New Orleans, Louisiana, December 4, arriving at Carrollton December 26, and duty there until March 1863.

Duty at Baton Rouge, Donaldsonville, Brashear City, and Berwick until October.

Attack on Fort Myers, Florida, February 20, 1865 (detachment).