It was noted for its holding the high ground at the center of the line at Antietam as part of Stainrook's 2nd Brigade, Greene's 2nd Division of Mansfield's XII Corps.

It remained in that vicinity until July, and then proceeded to Cedar Mountain, where it fought as part of the 2nd Brigade, 2nd Division, 2nd Corps.

Two months were spent in camp on Loudoun Heights, near Harper's Ferry, and with the 12th Corps, to which it had been transferred, the 111th arrived at Fredericksburg too late for the battle.

Winter quarters were established at Fairfax Station, the regiment leaving camp for the "Mud March" in Jan., 1863, after which it was sent to Acquia Creek and assigned to the 2nd Brigade, 2nd Division, 12th Corps.

On March 3, it was selected by Gen. Hooker as one of ten regiments to receive special commendation, practically shown by increase of absences and furloughs allowed.

In March, 1865, the 109th Pa. was consolidated with it and it moved on to Washington, where it participated in the grand review and on July 19, 1865, was mustered out of the service of the Union it had served so well.