Despite losing many of their officers and men, including Colonel Heenan, they remained at the wall until dark.

The 116th performed well at the Battle of Chancellorsville, where it helped rescue the 5th Maine Battery from capture.

On the second day of the Battle of Gettysburg, the 1st Division was sent into the Wheatfield to support the III Corps, where the 116th engaged in hand-to-hand combat.

During Pickett's Charge the following day, the regiment supported the 2nd Connecticut Battery but wasn't needed in the fighting.

Mulholland was wounded at the Battle of Spotsylvania Court House and Dale was missing in action.