Originally planned as a light artillery regiment, it was converted to an infantry unit and went to France as part of the 5th Marine Expeditionary Brigade in the waning days of the war.

Renewed political problems in Nicaragua and the intensified guerrilla campaign of the bandit leader Augusto Sandino caused the activation of another 11th Regiment at Norfolk, Virginia, and San Diego, California, in January 1928.

After its return to the United States from Cuba, the regiment (less the 1st Battalion) shipped overseas with the 1st Marine Division to New Zealand in June–July 1942.

In March 1945, the 11th Marines participated in the Battle of Okinawa, its final combat operation of World War II.

There the regiment played an important defensive role with effective counter-battery fire, and steadily suppressed enemy attempts to counter-attack objectives already won by U.S. forces.

With the war won, in the fall of 1945 the 11th Marines moved to Tianjin in North China as an element of Operation Beleaguer.

Shifted back to the east coast of Korea, the battalions were attached to regimental combat teams and participated in the Battle of Chosin Reservoir.

The ensuing fight would pit two artillery batteries against a battalion of Chinese infantry in broad daylight and at close range.

During the Cuban Missile Crisis of October 1962, the 11th Marines played a role in the task force ordered to impose a naval quarantine against arms shipments to Cuba.

The nature of the war required the artillerymen to defend their own positions against numerous enemy probes and brought about a vastly increased employment of artillery by helicopters, both for displacement and resupply.

Hastings, Hue City, Napoleon/Saline II, Mameluke Thrust, Oklahoma Hills, Pipestone Canyon and Imperial Lake were some of the more significant operations in which the regiment participated.

The 11th Marines participated in numerous training exercises throughout the 1980s to maintain the regiments high level of operational readiness.

[3] The regiment's ability to respond quickly to a crisis was put to the test in August 1990, when Iraq invaded and occupied its neighbor, Kuwait.

President George H. W. Bush immediately ordered American forces, including Marines, to the Persian Gulf, to deter a possible Iraqi assault into Saudi Arabia.

As the major coalition ground offensive began on 24 February, the 11th Marines was already inside Kuwait providing vital fire support to Task Forces Grizzly and Taro.

[3] Most recently, elements of the 11th Marine Regiment participated in the fight against the Islamic State in Syria as a part of Operation Inherent Resolve.