During the Indian Rebellion of 1857-58, the regiment, under the command of Major WG Duncan, operated in Central India against the Marathas led by Tatya Tope and the Rani of Jhansi.

In December 1857, it joined the Central India Field Force and during the next six months, fought in several major engagements, including the storming of the fortress of Rahatgarh, the Relief of Saugor, the capture of Jhansi and the Battle of Kalpi, where the Mahratta Army was decisively defeated.

It adopted uniform of drab colour with red trousers and its designation was changed to 24th (Baluchistan) Regiment of Bombay Infantry.

In 1896, it was dispatched to British East Africa under the command of Lieutenant Colonel AA Pearson to suppress a rebellion in areas now forming Kenya.

The 2nd Battalion served with great gallantry in the Mesopotamian Campaign, where it fought in the Battles of Khudaira Bend, Jebel Hamrin and Tikrit.

During the First World War, the three battalions of 124th DCO Baluchistan Infantry suffered a total of 1179 casualties including 459 killed or died of disease.