It did so by fighting in the advance until sundown, and by holding back the enemy while other regiments withdrew to a new point and waited the arrival of Maj. Gen. Don Carlos Buell.

Those members of the regiment who escaped capture at Shiloh, including future Speaker of the U.S. House of Representatives David B. Henderson, were assigned to the "Union Brigade."

The Union Brigade fought in the Second Battle of Corinth and others, before being sent to Davenport, Iowa, for re-organization, and remaining there during the winter of 1862–63.

Meanwhile, many of the members of the regiment who were captured at Shiloh were paroled on January 1, 1863, and exchanged at Benton Barracks, and soon thereafter went to Rolla, Missouri, which was threatened by the forces of Brigadier General John S. Marmaduke.

It was ordered to join the forces for the Meridian raid, but reached Vicksburg too late to take part, and went into camp.

In their absence, the non-veterans, numbering about 70, accompanied the 35th Iowa Volunteer Infantry Regimenton the Red River Campaign and was in battle at Lake Chicot.

Col. Stibbs, went to the mouth of the White River, established a military post and left A and F Companies under Captain J. R. C. Hunter.

Returning to Memphis, the regiment moved to La Grange, then to Holly Springs, Mississippi (via Lumpkin's Mills), remaining on duty there for some time.

A number of the enemy gained the stockade at one side, but Sergeant Isaac Cottle and Corporal George Hunter, armed with revolvers, attacked them and drove them out in confusion.

The entire besieging force was finally driven off, with over fifty killed (including their commanding officer), wounded or taken prisoner.

Joining the regiment at Holly Springs, this detachment accompanied it to Oxford, Mississippi, then to Memphis, and eventually to De Valls Bluff, Arkansas, and Brownsville in search of Maj. Gen. Sterling Price.

It joined in the pursuit of Nashville's attackers as far as Clinton, Tennessee, then proceeded to Eastport, Mississippi, where it assisted in building quarters and fortifications.

In the Battle of Spanish Fort the regiment fought in the front line and occupied an exposed position for thirteen days and nights.