It has command and control of more than 10,000 Army Reserve Soldiers throughout the southeastern United States in Alabama, Florida, Georgia, Louisiana, North Carolina, South Carolina, Tennessee, Arkansas and Mississippi.

It is made up of more than 100 Army Reserve units whose missions are diverse and logistical in nature.

Six months after the transition ceremony the 143rd ESC received a Department of the Army warning order for mobilization and deployment of the 143rd headquarters.

On 9 January 2009, the 143rd ESC deployed in support of the troop buildup in Afghanistan for Operation Enduring Freedom.

The mission of the 143d ESC during this deployment is to provide command and control of assigned forces, and to conduct sustainment, deployment, redeployment and retrograde operations in support of U.S. and multinational forces in the U.S. Central Command area of operations.