On 12 September 1634, a Hospitaller gunpowder factory in Valletta, Malta accidentally blew up, killing 22 people and causing severe damage to a number of buildings.

The factory had been built at some time in the late 16th or early 17th centuries, replacing an earlier one in Fort St. Angelo in Birgu.

It was located in the lower part of Valletta, close to the Slaves' Prison.

[1] The explosion damaged the nearby Jesuit church and college.

This factory was incorporated into the Ospizio complex in the early 18th century.