Activated in the summer of 2007, the brigade traces its lineage to the 7th and 16th Corps Support Groups which combined to form it.

[4] The group returned to the continental United States and was subsequently inactivated on 19 September 1968 at Fort Benning, Georgia.

[6] On 1 May 2002, the group was re-aligned to include the 181st Transportation Battalion located at Turley Barracks in Manheim, Germany, and the 485th Corps Support Battalion, located on Hutier Kaserne, to increase their combat service support capabilities.

[9] The 16th CSG also operated both the Air and Land Movement Control Centers with over rotary and fixed wing support for the 27th Movement Control Battalion and the 101st Airborne Division supply emergency support for camps and bases throughout Southern Iraq.

During this deployment the 16th CSG also operated a Military Transition Team in the Southern Baghdad Area.

One of the other missions of the 16th CSG was their "S5 Section" which was Civil Affairs[11] On 19 September 2006, the group rotated out of Iraq and back to Germany, replaced by the 82nd Sustainment Brigade.

[14] The sustainment brigade not only retained all previous logistics functions and responsibilities, but also assumed additional services, like finance, medical and signal capabilities.

[5] On 22 July 2008, the brigade's soldiers underwent final preparations before departing Rammstein Air Base for northern Iraq.

The brigade operated with US Air Force and Iraqi Army engineers to repair infrastructure that brought water from the Tigris River to the entire province, including the base.

The exercises involved extensive battle simulations and role play missions to test the overall effectiveness of the units.

[22] In October 2010, the brigade served as the command and control element for Saber Strike 11, a cooperative training effort aimed at improving interoperability and preparing Latvian, Estonian, Lithuanian and U.S. troops for upcoming deployments in support of the International Security Assistance Forces in Afghanistan.