The 1880–81 season was Northwich Victoria's 7th season,[1] however the club was not a member of an organised league and played only challenge matches organised on an ad hoc basis.

[2] The club won the Cheshire Senior Cup, then known as the Cheshire County Football Association Challenge Cup, for the second successive season.

[3] They also participated in the Welsh Cup for the third time, reaching the semi-final.

[4] The side was captained by Matthew Earlam for the 7th successive season.

[6] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.