The 1901 Ole Miss Rebels football team was an American football team that represented the University of Mississippi as a member of the Southern Intercollegiate Athletic Association (SIAA) during the 1901 SIAA football season.
In its first season under head coaches William Shibley and Daniel S. Martin, Ole Miss compiled a 2–4 record (0–4 against SIAA opponents) and was outscored by a total of 129 to 34.
A seventh game with Christian Brothers was canceled.
Right end F. W. Elmer was the team captain.
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