Charles Wade Liberal Reform James McGowen Labor The 1910 New South Wales state election was held on 14 October 1910 for all of the 90 seats in the 22nd New South Wales Legislative Assembly and it was conducted in single-member constituencies with a second ballot if a majority was not achieved on the first.

The 21st parliament of New South Wales was dissolved on 14 September 1910 by the Governor, Lord Chelmsford, on the advice of the Premier Charles Wade.

[a] There were 3 districts that required a second ballot, at Durham and St Leonards where the second round ballot was won by the leading candidate and at Hastings and Macleay where support from the Labour Party saw the independent overtake the sitting Liberal Reform member to take the seat.

The election saw the Labor Electoral League form government for the first time, winning 46 of the 90 seats in the Assembly.

The by-election in April 1910 was won by William Ashford (Labor) however Henry Willis regained the seat for Liberal Reform at the general election.