The schedule that Graduate Manager Hurst assembled was weaker than previous years as Carlisle, Notre Dame and Bucknell were missing.

Significant games played by Pitt during the 1910 season included victories over West Virginia (38–0), Washington & Jefferson (14–0), and Penn State (11–0).

In the second quarter the Pitt offense began to penetrate the Ohio defense and was on the Bears' five-yard line as time expired in the first half.

On the next possession Pitt halfback William Hittner broke the line of scrimmage and had clear sailing but tripped after gaining thirty-five yards.

Two minutes into the second quarter guard Henry Blair recovered a Westminster fumble by quarterback McClure on the Titan twenty-yard line.

Halfback Charles Quailey was replaced by William Hittner and Tillie Dewar stepped in at quarterback for Norman Budd to start the third quarter.

Pitt's halfback Rosenbloom fumbled away their first possession of the half on the Titan fourteen-yard line but Westminster promptly punted out of trouble.

The Pitt offense did not waste this possession as Captain Richards carried it into the end zone from the six for his second touchdown of the afternoon.

[3] On October 15, the Pitt football team opened the Forbes Field part of their schedule with resounding success against the Waynesburg Yellow Jackets.

Minutes later, Pitt scored on a seventy-five yard pass play from halfback Quailey to end Jack Lindsey.

The Pitt offense was able to advance the ball but both center Ralph Galvin and end Jack Lindsey missed field goals.

The Pittsburgh Daily Post noted "It was one of the most sensational drop kicks ever seen in the Smoky City and the spectators, seeing a chance to warm their chilled anatomies, howled with glee.

[6] On November 5, the steam-rolling Pitt football eleven achieved their sixth straight shutout victory by pummeling the West Virginia Mountaineers 38 to 0.

In the second quarter Pitt end Robert Peacock picked up another misplayed punt and scampered fifty yards for the score.

He promptly broke through the Pitt defense and barreled seventy yards before being tackled by Tex Richards on the ten-yard line.

The Pittsburgh Daily Post wrote "The Pitt captain's offensive work stood out all day, as it has in practically every game of the season, and when he made good in the "ultimate moment," for any football artist, by such a beautiful tackle, in the face of strong interference, his admirers gave full vent of their feelings.

At the start of the second half, Mountaineer halfback Kinsey had his chewing gum lodge in his throat when being tackled and he had to be rushed to the hospital.

Dewar excited the crowd with a seventy-five yard touchdown scamper that was called back due to a holding penalty.

Four plays later he carried the pigskin into the end zone from the fourteen and Galvin nailed the extra point to close the scoring.

[7] On November 12, the Washington & Jefferson Red and Black tried to defeat the so far undefeated, untied, and unscored upon Pitt eleven at Forbes Field.

Early in the second quarter the Pitt offense moved the ball to the W. & J. six-yard line and fullback Tex Richards fumbled.

Pitt guard George Bailey and Red and Black quarterback Forsythe traded punches and the officials disqualified them both.

With less than five minutes to go in the game Tex Richards completed a forward pass to Norman Budd on the Red and Black three-yard line.

[8] On November 11, the Tartans of Carnegie Tech closed their season at Forbes Field against city neighbor and rival Pitt.

Halfback Charles Quailey completed a long pass to end Jack Lindsey to the Tech two-yard line.

Dave Richards scored a touchdown in the fourth quarter and Galvin made the extra point to make the final tally 35 to 0.

[9] On Thanksgiving afternoon eighteen thousand fans from all parts of the state congregated at Forbes Field to see if the Pitt eleven could complete the season unbeaten, untied and unscored upon.

Rain fell during the second half which caused some slipping by the running backs but the crowd stayed until the referee called time.

State fans were encouraged when center Watson intercepted a pass and had a clear field in front of him but he slipped on the mud.

A few possessions later Norman Budd returned a punt fifty-five yards for a touchdown but Pitt was called for an illegal block.